Chronic Bacterial Rhinosinusitis

Biophysical Effects on Chronic Rhinosinusitis Bacterial Biofilms

Implications of bacterial biofilms in chronic rhinosinusitis.

The recognition of sessile form of bacteria with particular features, known as biofilm, has given new insights to the understanding of pathogenesis of several chronic diseases, including Chronic Rhinosinusitis (CRS). In this article we review the main characteristics of biofilms, describe the current methods used to demonstrate biofilms in chronic rhinosinusitis and discuss the future direction...

Bacterial biofilms and the pathophysiology of chronic rhinosinusitis.

PURPOSE OF REVIEW To review the evidence for the presence of bacterial biofilms in chronic rhinosinusitis (CRS) and mechanisms by which they may contribute to the chronic inflammation characteristic of this disease. Lastly, to provide an overview of the current and potential future treatments for bacterial biofilms in CRS. RECENT FINDINGS Advances in the techniques for identifying biofilms ha...

Bacterial Communities Vary between Sinuses in Chronic Rhinosinusitis Patients

Chronic rhinosinusitis (CRS) is a common and potentially debilitating disease characterized by inflammation of the sinus mucosa for longer than 12 weeks. Bacterial colonization of the sinuses and its role in the pathogenesis of this disease is an ongoing area of research. Recent advances in culture-independent molecular techniques for bacterial identification have the potential to provide a mor...

Chronic rhinosinusitis in children.

Chronic rhinosinusitis (CRS) affects nearly 37 million people in the United States each year and accounts for approximately $6 billion in direct and indirect health care costs. Despite its prevalence and significant impact, little is known about its exact cause and pathophysiology, and significant controversy remains regarding appropriate treatment options. Basic science research, however, has ...